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KMID : 0376619920170030202
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Seoul Journal of Psychiatry
1992 Volume.17 No. 3 p.202 ~ p.211
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Imaging Cerebrai Blood Flow in Schizophrenics by Single-Photon Emission Computed Tomography with Tc-99m-HMPAO
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Abstract
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The single-photon emission computed tomography (SPECT) is an unique method to monitor the regional cerebral blood flow three dimensionally. Clinically, it has a limited to the research field rather than the clinical purpose Even in Korea, there
are
only
few papers concerned about SPECT using xenon inhalation technique. Therefore, this is the first study of regional cerebral blow flow mapping in twelve schizophrenic patients using 99mTc as a radiotracer.
Most of the SPECT results except one revealed hypoperfusion pattern(91.7%). The most prevalent loci of the lowest perfusion were bilateral parietal areas (p<0.05), followed by left parietal, left temporal and bilateral frontal, and then
cerebellum,
and
the last basal ganglia and thalamus.
Comparing a spectrum produced by enlisting eight cases of a neurosis, a major depression with psychotic features, a schizotypal personality disorder, a residual schizophrenia, subchronic paranoid schizophrenia with acute exacerbation, subchronic
paranoid schizophrenia without acute exacerbation, chronic undifferentiated schizophrenia with acute exacerbation, chronic undifferentiated schizophrenia without acute exacerbation in decrease order of perfusion, the cerebral blood flow changes
tended
to be related with the intensity of psychotic symptoms and duration of illness.
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KEYWORD
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